Cutting Edge : Failure of Antigen-Specific CD4+ T Cell Recruitment to the Kidney during Systemic Candidiasis

Copyright © 2014 The Authors. Acknowledgments We thank E. Bolton and H. Bagavant for reagents and advice. We also acknowledge the staff of the Medical Research Facility at the University of Aberdeen for care of the animals used in this study. This work was supported by the Medical Research Council and the Wellcome Trust.Peer reviewedPublisher PD

GTC OSIRIS transiting exoplanet atmospheric survey: detection of sodium in XO-2b from differential long-slit spectroscopy

We present two transits of the hot-Jupiter exoplanet XO-2b using the Gran Telescopio Canarias (GTC). The time series observations were performed using long-slit spectroscopy of XO-2 and a nearby reference star with the OSIRIS instrument, enabling differential specrophotometric transit lightcurves capable of measuring the exoplanet's transmission spectrum. Two optical low-resolution grisms were used to cover the optical wavelength range from 3800 to 9300{\AA}. We find that sub-mmag level slit losses between the target and reference star prevent full optical transmission spectra from being constructed, limiting our analysis to differential absorption depths over ~1000{\AA} regions. Wider long slits or multi-object grism spectroscopy with wide masks will likely prove effective in minimising the observed slit-loss trends. During both transits, we detect significant absorption in the planetary atmosphere of XO-2b using a 50{\AA} bandpass centred on the Na I doublet, with absorption depths of Delta(R_pl/R_star)^2=0.049+/-0.017 % using the R500R grism and 0.047+/-0.011 % using the R500B grism (combined 5.2-sigma significance from both transits). The sodium feature is unresolved in our low-resolution spectra, with detailed modelling also likely ruling out significant line-wing absorption over an ~800{\AA} region surrounding the doublet. Combined with narrowband photometric measurements, XO-2b is the first hot Jupiter with evidence for both sodium and potassium present in the planet's atmosphere.Comment: 9 pages, 10 figures, 1 table, accepted for publication in MNRA

Gran Telescopio Canarias OSIRIS Transiting Exoplanet Atmospheric Survey: Detection of potassium in XO-2b from narrowband spectrophotometry

We present Gran Telescopio Canarias (GTC) optical transit narrow-band photometry of the hot-Jupiter exoplanet XO-2b using the OSIRIS instrument. This unique instrument has the capabilities to deliver high cadence narrow-band photometric lightcurves, allowing us to probe the atmospheric composition of hot Jupiters from the ground. The observations were taken during three transit events which cover four wavelengths at spectral resolutions near 500, necessary for observing atmospheric features, and have near-photon limited sub-mmag precisions. Precision narrow-band photometry on a large aperture telescope allows for atmospheric transmission spectral features to be observed for exoplanets around much fainter stars than those of the well studied targets HD209458b and HD189733b, providing access to the majority of known transiting planets. For XO-2b, we measure planet-to-star radius contrasts of R_pl/R_star=0.10508+/-0.00052 at 6792 Ang, 0.10640+/-0.00058 at 7582 Ang, and 0.10686+/-0.00060 at 7664.9 Ang, and 0.10362+/-0.00051 at 8839 Ang. These measurements reveal significant spectral features at two wavelengths, with an absorption level of 0.067+/-0.016% at 7664.9 Ang due to atmospheric potassium in the line core (a 4.1-sigma significance level), and an absorption level of 0.058+/-0.016% at 7582 Ang, (a 3.6-sigma significance level). When comparing our measurements to hot-Jupiter atmospheric models, we find good agreement with models which are dominated in the optical by alkali metals. This is the first evidence for potassium in an extrasolar planet, an element that has long been theorized along with sodium to be a dominant source of opacity at optical wavelengths for hot Jupiters.Comment: 11 pages, 6 figures, accepted in A&A, minor changes to wording, primarily section 4.2, and the title has also been slightly modifie

Heat capacity of the quantum magnet TiOCl

Measurements of the heat capacity C(T,H) of the one-dimensional quantum magnet TiOCl are presented for temperatures 2K < T < 300K and magnetic fields up to 5T. Distinct anomalies at 91K and 67K signal two subsequent phase transitions. The lower of these transitions clearly is of first order and seems to be related to the spin degrees of freedom. The transition at 92K probably involves the lattice and/or orbital moments. A detailed analysis of the data reveals that the entropy change through both transitions is surprisingly small (~ 0.1R), pointing to the existence strong fluctuations well into the non-ordered high-temperature phase. No significant magnetic field dependence was detected.Comment: 4 pages, 2 figure

HST/STIS Optical Transit Transmission Spectra of the hot-Jupiter HD209458b

We present the transmission spectra of the hot-Jupiter HD209458b taken with the Space Telescope Imaging Spectrograph aboard the Hubble Space Telescope. Our analysis combines data at two resolutions and applies a complete pixel-by-pixel limb-darkening correction to fully reveal the spectral line shapes of atmospheric absorption features. Terrestrial-based Na I and H I contamination are identified which mask the strong exoplanetary absorption signature in the Na core, which we find reaches total absorption levels of ~0.11% in a 4.4 Ang band. The Na spectral line profile is characterized by a wide absorption profile at the lowest absorption depths, and a sharp transition to a narrow absorption profile at higher absorption values. The transmission spectra also shows the presence of an additional absorber at ~6,250 Ang, observed at both medium and low resolutions. We performed various limb-darkening tests, including using high precision limb-darkening measurements of the sun to characterize a general trend of Atlas models to slightly overestimate the amount of limb-darkening at all wavelengths, likely due to the limitations of the model's one-dimensional nature. We conclude that, despite these limitations, Atlas models can still successfully model limb-darkening in high signal-to-noise transits of solar-type stars, like HD209458, to a high level of precision over the entire optical regime (3,000-10,000 Ang) at transit phases between 2nd and 3rd contact.Comment: 18 pages, 11 figures, Accepted to Ap

Corrigendum to "The upper atmosphere of the exoplanet HD209458b revealed by the sodium D lines: Temperature-pressure profile, ionization layer and thermosphere" [2011, A&A, 527, A110]

An error was detected in the code used for the analysis of the HD209458b sodium profile (Vidal-Madjar et al. 2011). Here we present an updated T-P profile and briefly discuss the consequences.Comment: Published in Astronomy & Astrophysics, 533, C

Physical transformations between quantum states

Given two sets of quantum states {A_1, ..., A_k} and {B_1, ..., B_k}, represented as sets of density matrices, necessary and sufficient conditions are obtained for the existence of a physical transformation T, represented as a trace-preserving completely positive map, such that T(A_i) = B_i for i = 1, ..., k. General completely positive maps without the trace-preserving requirement, and unital completely positive maps transforming the states are also considered

Pressure dependence of the Verwey transition in magnetite: an infrared spectroscopic point of view

We investigated the electronic and vibrational properties of magnetite at temperatures from 300 K down to 10 K and for pressures up to 10 GPa by far-infrared reflectivity measurements. The Verwey transition is manifested by a drastic decrease of the overall reflectance and the splitting of the phonon modes as well as the activation of additional phonon modes. In the whole studied pressure range the down-shift of the overall reflectance spectrum saturates and the maximum number of phonon modes is reached at a critical temperature, which sets a lower bound for the Verwey transition temperature T$_{\mathrm{v}}$. Based on these optical results a pressure-temperature phase diagram for magnetite is proposed.Comment: 5 pages, 4 figures; accepted for publication in J. Appl. Phy